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Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis
Sec. Pharmacology of Infectious Diseases / 2023View Publication
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In vivo pharmacodynamic study of contezolid acefosamil, a prodrug of contezolid for oral and intravenous administration
Journal of Antimicrobial Chemotherapy / 2023View Publication
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A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects
Antimicrobial Agents and Chemotherapy / 2023View Publication
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A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo
Antimicrobial Agents and Chemotherapy / 2022View Publication
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Discovery of Antibacterial Contezolid Acefosamil: Innovative O-Acyl Phosphoramidate Prodrug for IV and Oral Therapies
ACS Med. Chem. Lett. / 2022View Publication
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Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections
Antimicrobial Agents and Chemotherapy / 2022View Publication
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A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections
Journal of Antimicrobial Chemotherapy / 2022View Publication
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A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
Antimicrobial Agents and Chemotherapy / 2021View Publication
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Pharmacokinetics and Disposition of Contezolid in Humans: Resolution of a Disproportionate Human Metabolite for Clinical Development
Antimicrobial Agents and Chemotherapy / 2021View Publication
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Nonclinical Evaluation of Antibacterial Oxazolidinones Contezolid and Contezolid Acefosamil with Low Serotonergic Neurotoxicity
Chem Res Toxicol / 2021View Publication
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Pharmacodynamic Evaluation of MRX-8, a Novel Polymyxin, in the Neutropenic Mouse Thigh and Lung Infection Models against Gram-Negative Pathogens
Antimicrobial Agents and Chemotherapy / 2020View Publication
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In Vitro Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe
Antimicrob Agents Chemother / 2020View Publication
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