发表论文

  1. Meng, J.; Zhong, D.; Li, L.; Yuan, Z.; Yuan, H.; Xie, C.; Zhou, J.; Li, C.; Gordeev, M.F.; Liu, J. Metabolism of MRX-​I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,​3-​dihydropyridin-​4-​one catalyzed by non-​P450 enzymes. Drug Metab. Disposition, 201543, 646-59.
  2. Gordeev, M.F.; Yuan, Z. New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J. Med. Chem. Drug Annotation, 2014, 57, 4487−4497.
  3. Huang, Y.; Xu. X.; Guo, Q.; Xu, Y.; Liu, S; Wang, H.; Wu, B.; Gordeev, M. F.; Wang, W.; Yuan, Z. Selection and characterisation of Staphylococcus aureus mutants with reduced susceptibility to the investigational oxazolidinone MRX-​I. J Antimicrobial Agents, 2014, 43, 418-22.
  4. Zhu, D. M.; Wang W; Huang, Y. Q.; Zhang, Y.Y. Antibacterial spectrum of oxazolidinone MRX-I: potent activity against multidrug-resistant Gram-positive pathogens. Poster F-1497. 52nd Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  5. Huang, Y. Q. ; Wang, W.; Li, Y.; Wang, H.L.; Xu, Y.H.; Liu, C.; Zhou, F.; Wang, C.Q.; Liu, J.; Wang, Q. Antimicrobial profile of MRX-I: resistance and drug combination studies. Poster F-1498. 52nd Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  6. Li, C.R.; Li, G.Q.; Hu, X.X.; Zhang, W.X.; Wang, X.K.; Pang, J.; Lu, X.; Zhai, Q. Q.; Yuan, H.; Gordeev, M.F.; Yang, X.Y.; You, X.F. Novel oxazolidinone MRX-I is efficacious in mouse models of Gram-positive bacterial infections. Poster F-1499. 52nd Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  7. Chen, Y.; Gao, Z.W.; Yuan, H.; Yuan, Z.Y.; Zhong, D.F. Pre-clinical pharmacokinetics of MRX-I in rodents and dogs. Poster F-1500. 52nd Intersci. Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  8. Wang, W.; Wang, Z.; Chang, Y.; Yuan, H.; Yuan, Z.Y.; Zhou, J.L.; Zhong, D. F. In vitro safety study of MRX-I, a safer oxazolidinone antibacterial agent. Poster F-1501. 52nd Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  9. Qiu, L.; Jiang, J.Q.; Huang, H.X.; Hsu, C. H.; Ma, J.; Yuan, H; Gordeev, M. F. Acute and repeat dose toxicity of MRX-I in rat. Poster F-1502. 52nd Intersci. Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  10. Zhang, ; Wu, X.J.; Huang, J.; Yu, J.C.; Guo, B.N.; Cao, G.Y.; Wu, J. F.; Zhang, K. J.; Yuan, H.; Yuan, Z.Y.; Shi, Y.G.; Zhang, Y.Y. Single oral dose pharmacokinetics of MRX-I in healthy subjects. Poster F-1503. 52nd Intersci. Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.
  11. Zhang, ; Wu, X.J.; Huang, J.; Yu, J.C.; Guo, B.N.; Cao, G.Y.; Wu, J. F.; Yuan, H.; Yuan, Z.Y.; Shi, Y.G.; Zhang, Y.Y. Hematological effect and pharmacokinetics of multiple oral dose MRX-I in healthy subjects. Poster F-1504. 52nd Intersci. Conf. Antimicrob. Agents Chemother. 2012, San Francisco, USA.